SHORT TERM REAL WORLD SAFETY DATA OF PERTUZUMAB USE IN HER2 TARGETED TREATMENT OF METASTATIC BREAST CANCER

Introduction: With the development and widely use of HER2 targeted therapies, HER2 expressing metastatic breast cancer have no longer dismal prognosis as once expected.The combination of HER2 targeted therapies with chemotherapatic agents prolongs overall survival.Pertuzumab is a new monoclonal antibody molecule that binds to the extracellular port

Background and Purpose: Inverse treatment planning for lung cancer can be challenging since density heterogeneities may appear inside the planning target volume (PTV).One method to improve the quality of intensity modulation is the override of low density tissues inside the PTV during plan optimization.For magnetic resonance-guided radiation therap